RNA Modifications
Comprehensive chemical toolkit
Cirena specializes in incorporating custom modifications at defined positions in long RNA. This includes backbone chemistries that improve in-cell durability, to functional labels for localization and binding studies.
Sugar
Backbone
Functional labels
End modifications
Base analogs
Backbone chemistries — improved in-cell durability
Sugar modifications
Functional labeling
End modifications — reduce exonuclease degradation
Base analogs — regulatory or structural mimicry
How Cirena ensures structure integrity
01
High-fidelity chemical synthesis minimizes sequence defects that disrupt helices, loops, and long-range RNA interactions.
02
Proprietary purification methods remove truncated species and chemical adducts that interfere with folding.
03
Proprietary QC analytics verify integrity and molecular assembly on every RNA produced.
04
Modification compatibility testing ensures stabilizing chemistries are added without perturbing functional folding domains.
In cells, the PACE modification is two orders of magnitude more stable than standard protection — enabling longer in vivo half-lives without immune activation.
Custom chemistries
Don't see what you need?
Cirena's synthesis capabilities extend well beyond our standard catalogue. If you require a modification not listed above — whether a novel backbone chemistry, an unusual label, or a position-specific combination — just ask. Our team will assess feasibility and work with you directly to design the right solution.
Get started
Ready to advance your RNA program?
Submit your sequence for a free feasibility check or request a quote — our team responds within 24 hours.
Free feasibility check
rnatech@cirena.com
Request a quote
sales@cirena.com