Ordering is straightforward — just send us the following for each sequence, in any format you prefer (email, Word, or Excel all work great):

Oligo ID / Name: A unique label for each sequence (e.g., "sgRNA-target-1"). This keeps everything organized, especially for multi-sequence orders.

Sequence (5' → 3'): Your RNA sequence in standard single-letter nucleotide code. Please provide it 5' to 3'.

Synthesis Quantity: Let us know how much you need, specified in nanomoles (nmol) or micrograms (µg).

Modifications & Linkages: Note any chemical modifications — backbone chemistries (like phosphorothioate or our proprietary PACE modification), sugar modifications (2'-OMe, 2'-F, LNA), functional labels (biotin, fluorophores), end modifications, or base analogs (pseudouridine, m6A). Our catalogue is at cirena.com/rna-modifications. Don't see what you need? Just ask — we love a good challenge. Send orders or questions to sales@cirena.com and we'll get back to you within 24 hours.

Great question - long RNA is worth protecting carefully, and it's easier than you might think.

Your RNA will be shipped lyophilized; this is the most stable form for long-term storage. Keep it at -20°C in a desiccated environment, and you're looking at a shelf life of up to 36 months. Once resuspended, working aliquots are fine at 4°C for up to a month. Try to avoid repeated freeze-thaw cycles (we recommend no more than five).

A few habits that make a real difference: always use RNase-free tips, tubes, and gloves; store in low-binding polypropylene tubes (like Eppendorf LoBind®); and if your product is fluorescently labeled, keep it away from light.

When you're ready to resuspend, let the sealed tube come to room temperature for ~5 minutes before opening - this prevents condensation from sneaking in.

More questions? We're happy to help.

‍ The honest answer is: it depends on length, quantity, purity, and modifications. Here's what to expect for HPLC-purified orders under 30 nmol:

‍ ‍Length Turnaround Time

‍ Up to 150 nt 12–15 business days‍

‍ 151–200 nt 15–20 business days

‍ Over 200 nt 20–25 business days

‍ ‍These times run from order acceptance to shipment, so please add transit time for your location when planning experiments.

A few things worth knowing. Longer sequences require more synthesis cycles and more demanding purification, both take time to do right. Certain modifications can also affect turnaround, so if your order includes anything complex, we'll flag it upfront. For quantities above 30 nmol, timelines vary — just reach out sales@cirena.com and we'll work through the details together.

We combine a thoughtful, human-centered approach with clear communication and reliable results. It’s not just what we do—it’s how we do it that sets us apart.