High-Purity 100-300nt RNA Synthesis

Supporting Gene Editing, Circular RNA, and Non-Coding RNA Research

Empowering Exploration into the Next RNA Frontier

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Long RNA in the 100–300 nt range sits in a gap that other synthesis methods struggle to fill, especially at high purity. Cirena's proprietary chemistry closes that gap, so ordering research-grade long RNA is as straightforward as ordering any other reagent.

Our Promise.

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  • Our chemistry works with numerous modifications including the phosphonoacetate (PACE) modification.

    Examples:

    DNA, 2’O-Methyl, Phosphorothioate (PS), Phosphonoacetate (PACE)

  • We deliver only the highest-purity RNA. All oligos are purified by liquid chromatography (LC) and shipped with mass spectrometry (MS) data. Every oligo meets rigorous analytical standards for identity and quality.

  • We understand that your experiments are waiting. From design to delivery, our streamlined synthesis and purification workflow ensures rapid production without compromising quality. Ready for immediate use in your research.

  • This chemistry is the product of decades of work by our co-founders whose research eventually led to Cirena's spinout. As your project grows, so will we. We offer quantities from microgram to gram scales.

    Cirena maintains close relationships with leading CDMOs, enabling seamless scale-up to larger production volumes. The pathway to GMP manufacturing is straight forward.

Featured Applications

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Custom long RNAs enable precise control in CRISPR and gene-modification systems. We are excited to aid in the optimization of novel editors. Our PACE modification supports higher editing efficiency and reliable guide RNA performance.

Gene Editing

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Synthetic long RNAs are key for restoring or modulating gene function. We provide high-quality, sequence-verified RNA ideal for therapeutic research and preclinical development.

RNA Replacement Therapeutics

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Our oligos are optimized for folding accuracy and chemical stability, supporting structural and biophysical studies of RNA interactions and small molecule dynamics.

Structural & Folding Studies