Cirena developed a commercially proven, modern, high-performance platform for the solid-phase chemical synthesis of long RNA up to 300 nt, far surpassing the capabilities of conventional RNA synthesis methods.

Powered by proprietary 2′-O-Thionocarbamate (TC) nucleoside phosphoramidites, our technology has provided robust, high-yield production of thousands of RNA oligonucleotides, including:

• pegRNAs up to 250 nt

• lncRNA subunits up to 300 nt

• custom modified RNAs for enhanced stability, activity, and specificity

These sequences are purified with a single-step, affinity-assisted chromatography method developed in-house. The result is a streamlined, scalable workflow suitable for clinical-grade investigations.

As CRISPR and non-coding RNA technologies evolve, our long-RNA chemistry provides the reliability, flexibility, and precision needed to support advanced research and therapeutic development. Our ongoing innovation continues to push the boundaries of RNA length, purity, and chemical customization, empowering the next era of RNA-based research.